1. On what does the initial rate of drug distribution heavily depend?

2. How do tumors or abscesses affect drug distribution?

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3. Explain the blood–brain barrier in relation to drug distribution.

4. List the factors that affect the rate of drug absorption.

1. Which type of drug tolerance is a reductio in response to a drug caused by repeated doses over a short period of time?

2. List the main route of drug excretion and the factors that may change it.

3. List and briefly explain the three steps of renal excretion.

4. Which alternate route is important for excretion of alcohol and anesthetic gases?

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