1. Why must therapeutic drugs be approved by the Food and Drug Administration (FDA)?

2. What are the four stages of drug approval?

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3. Describe clinical stage trials.

4. List the three most famous examples of drugs being withdrawn after postmarketing surveillance.

5. A 52-year-old female was suffering from constipation for 4 days, and bought an OTC drug for this condition. Also, her sister advised her to take the herbal supplement Cascara sagrada.

1. What are the indications of Cascara sagrada?

2. If this patient took the drug and the supplement together, what may be the effects?

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